网站首页
概要
MLN4924 inhibits cullin neddylation by directly targeting the NEDD8-activating enzyme that is essential for the activity of cullin-RING ligase (CRL) (Nawrocki et al.). The components of CRL are frequently up-regulated in human cancers (Zhao & Sun), and MLN4924 was reported to suppress the growth of human tumor xenografts in mice (Soucy et al.).
GENOME EDITING
· In combination with other small molecules (“CRISPY” mix), MLN4924 has been reported to increase precise CRISPR-Cas9 genome editing in human pluripotent stem cells (Riesenberg & Maricic).
CANCER RESEARCH
· By blocking NAE and proteasome, MLN4924 together with bortezomib inhibits AKT and mTOR and induces apoptosis in multiple myeloma cell lines (Gu et al.).
GENOME EDITING
· In combination with other small molecules (“CRISPY” mix), MLN4924 has been reported to increase precise CRISPR-Cas9 genome editing in human pluripotent stem cells (Riesenberg & Maricic).
CANCER RESEARCH
· By blocking NAE and proteasome, MLN4924 together with bortezomib inhibits AKT and mTOR and induces apoptosis in multiple myeloma cell lines (Gu et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | MLN4924 | 74182, 74184 | All | English |
| Safety Data Sheet | MLN4924 | 74182, 74184 | All | English |
