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概要
FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
技术资料
| Document Type | 产品名称 | Catalog # | Lot # | 语言 |
|---|---|---|---|---|
| Product Information Sheet | FK506 | 74152, 74154 | All | English |
| Safety Data Sheet | FK506 | 74152, 74154 | All | English |
